Solaray Guggul and Red Yeast Rice Supplement, 60 Count
Rice Supplement - College Confidential
This research study was approved by the Institutional Review Board (Human Subject Protection Review Committee) of the University of California, Los Angeles. Procedures followed were in accord with the ethical standards set forth in the Helsinki Declaration of 1975 as revised in 1983. As required by the Human Subject Protection Review Committee, all subjects were told about possible rare side effects of liver and muscle toxicity observed with cholesterol-lowering drugs. All subjects provided written, informed consent to participate. Patients were randomly assigned to the Chinese red-yeast-rice dietary supplement– (Cholestin, Pharmanex, Inc, Simi Valley, CA) and placebo-treated groups.
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Studies in humans have been conducted in China with both more and less concentrated extracts of the red yeast rice than in our red-yeast-rice–treated group. In 324 hypercholesterolemic subjects treated with Xuezhikang (1.2 g/d containing 13.5 mg total monacolins) for 8 wk, serum cholesterol concentrations decreased by 23%, triacylglycerols decreased by 36.5%, and HDL-cholesterol concentrations increased by 19.6%. Two to 4 wk before the initiation of this study, subjects were instructed to cease taking all medications and were provided with dietary counseling (). In a second study, an earlier version of the red-yeast-rice supplement containing 10–13 mg total monacolins was given to 101 hypercholesterolemic subjects. Total cholesterol decreased by 19.5% and triacylglycerol decreased by 36.1% in the treated group. HDL-cholesterol concentrations increased by 16.7% in this study (). These and other Chinese studies were similar to this study in showing a marked effect of the constituents of this dietary supplement on cholesterol concentrations. However, there were differences in the ethnicity and serum lipid concentrations of the populations studied. Furthermore, a rice placebo was used in the present study in a double-blind fashion, whereas the Chinese studies used different natural preparations in the comparison group rather than a matched placebo capsule.